The Council sponsors a variety of programs and activities during the course of each year. Members are informed of Council-sponsored events and initiatives through email communications. An Annual Student Work Experience Scholarship program is operated by the Council in which undergraduates from Irish Universities are assigned temporarily to work in American corporations. The Council also operates a program for post-graduate American students who work as management interns for companies in Ireland.

Each year, Council members visit Ireland. The Council are available to help structure itineraries of these visits to include briefings of visiting Council members on topics of current interest by Cabinet Ministers, senior Government officials and prominent Irish business people. In the United States, the Council also sponsors regular luncheon meetings and other events to host distinguished visitors. The Council stages an annual Winter Meeting in Florida each February.

Through its Award for Outstanding Achievement, presented each year at the Annual Dinner, the Council honors persons who have made significant contributions to the development of closer economic, business or commercial ties between the two countries. The Council's Annual Award is a citation of distinction which has been presented to some of the leading figures in Ireland and in the United States.

The Council also supports arts education in Ireland through the Portraitist of the Year Award.